Evaluation of the effects of Momordica charantia on tibial defect injury in rats

We aimed to examine the histological and immunohistochemical effects of Momordica charantia on bone repair, which provides positive regulation such as blood sugar, pressure, antilipidemic, anticarcinogenic, antibacterial, antioxidant, anti-inflammatory, wound healing, tissue regeneration in rats with tibial defect. (MC) (commonly called bitter melon; Goya; apple; gourd; squash; balsam-pear; many more names listed below) is a tropical subtropical vine family Cucurbitaceae, widely grown Asia, Africa, Caribbean for its edible fruit. Its varieties differ substantially shape bitterness In this study, 32 male Sprague Dawley rats, 12 weeks old weighing 250-300gr, were used. 8 each group randomly, 1st control, 2nd defect (Sham), 3rd + MC (14 days), 4th (28 days) separated into group. experimental 600 mg/kg/day (bitter melon) extract was mixed drinking water groups 3 4 administered by oral tube. One 6 mm diameter cylindrical defects created body right tibia bone. No action taken Group 1. 2, only made. For 14 days 28 4, given gavage. Elevated Malondialdehyde (MDA) levels Myeloperoxidase (MPO) decreased. osteoblastic activity osteocyte development increased, while osteopontin osteonectin expression found be positive, osteoclastic decreased compared sham It good antioxidant where applied. has been observed that it can have effect repair.
 Keywords: charantia; Tibial defect; Fracture healing; Bone repair; Antioxidant